Royal Bank of Scotland (RBS), the state-owned bank, is to cut 1,400 more jobs.
The majority will go at its Edinburgh head office in the retail division.
The company has already lost 35,000 jobs since it needed government money to bail it out in 2008.
It confirmed that no customer-facing roles would be lost.
Ross McEwan, the chief executive of RBS's UK retail operations, said: "To serve our customers well, we have to ensure that our resources are focused on the things that matter most to them.
"Regrettably, we can only do that by restructuring the way we work in head office, so that every effort is concentrated on supporting our customers and the frontline staff that serve them.
"This is clearly difficult news for our staff and we will do everything we can to support them, including seeking redeployment opportunities wherever possible to ensure compulsory redundancies are a last resort."
But the Unite union, which represents many of RBS's staff, called the cuts "brutal".
The news will surprise some, with the bank returning to profit in the first three months of 2013 after big losses last year.